3-Drug Intracavernosal Injection

At a Glance

  • A mixture of three medications
  • Inject into shaft of penis 5 to 15 minutes prior to intercourse
  • Effective for 1 to 2 hours
  • Available in 11 formulations, prescription required

The Details

Trimix injections work by relaxing the corporal smooth musculature. This allows for increased blood flow to the penis to achieve and maintain an erection strong enough for the entirety of sexual intercourse.

Trimix should be injected 5-15 minutes prior to sexual activity.

Prescription Required
menMD does not compound or dispense prescription products. Prescriptions are filled through our US-licensed pharmacy partners.

Starts at $92.70 per 5mL Vial

Get Started with Trimix

What to know about Trimix

How it Works

Trimix is injected into the cavernosal tissue of the penis with a very fine needle just before intercourse. The medication works by relaxing the corporal smooth musculature and/or building the adrenergic tone of the corporal smooth muscle.

This allows for Increased blood flow to the penis to achieve and maintain an erection strong enough for the entirety of sexual intercourse.

Who’s it For?

Trimix injections are recommended for men who suffer from erectile dysfunction. Trimix may also be used in conjunction with other Erectile Dysfunction therapy modalities such as PDE5-inhibitors.

DO NOT inject Trimix more than once in a 24-hour period unless instructed to do so by your Physician. Patients must be cautioned to call their physician if an erection persists for 4 hours or longer.

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Injections are one of the most effective forms of ED treatment: up to 92% of patients find it effective. In a study conducted by the British Medical Journal, 88% of patients who failed to respond to PDE5-Inhibitors (Viagra, Cialis, Levitra) were successful with injection therapy. Additionally 48% of men who failed to respond to PDE5-inhibitors responded when used in conjunction with injection therapy.

According to a Continuing Medical Education (CME) Article, of the men who stop using injection therapy, 82% of them would still recommend it to a friend.

Off-Label Uses

A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For Trimix, there are a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.

FDA Approved Use

Trimix is often recommended for men suffering from more advanced erectile dysfunction or who have other comorbidities impacting their ED.

Prostate Cancer

Trimix may be prescribed for men who have just had a radical prostatectomy for prostate cancer. Injection Therapy is commonly used to aid in the recovery process.

Medical Chart

Trimix Side Effects

  • Priapism (erection lasting more than 4 hours)
  • Aching sensation in penis
  • Scarring at injection site (if injections aren’t rotated)

Good to Know

Do not exceed the maximum prescribed dose without consulting your urologist. Do not inject more than once in a 24-hour period unless otherwise directed by your physician. Most doctors recommend no more than 3-4 times weekly to minimize scar tissue formation.

All vials, whether punctured or sealed, must be refrigerated. Trimix multi-use vials are safe to use up to 28-days after the first puncture. Do not freeze.

Ready to Get Results?

Use these tools to rate and track your progress.

Rigidity Scale
Use this tool to rate your erection. The goal range is 7-9 with 6 being firm enough for penetration.

Log Your Progress
Use the chart below to record your progress. This chart comes in handy when discussing your treatment success with your provider or with a menMD Personal Health Assistant.

Learn more or download the Injection Therapy Guide, which includes these tools, in the resource center.

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Available in 5mg and 20mg tablets or lozenges, prescription required.



Injection therapy, the most effective treatment for ED, is injected into the shaft of the penis 5-15 minutes prior to intercourse.

4 drug mixture, prescription required.