Inject into urethra of penis with needleless syringe 5 to 15 minutes prior to intercourse
Effective for up to 1 hour
Available in 3 formulations, prescription required
The Details
Intraurethral gel works to relax smooth muscle in the penis and increase blood flow to the cavernosal chambers to achieve an erection strong enough for sexual intercourse or for penile rehabilitation. Intraurethral Gel is a one or two drug formulation consisting of Alprostadil and/or Phentolamine.
Intraurethral Gel should be used 5-15 minutes prior to sexual activity.
Prescription Required menMD does not compound or dispense prescription products. Prescriptions are filled through our US-licensed pharmacy partners.
Intraurethral gel is inserted into the urethra of the penis using a preloaded needleless syringe just before intercourse. The medication works by relaxing the smooth muscle in the penis allowing increased blood flow to the cavernosal chambers. Intraurethral Gels are formulated with one or two FDA approved ingredients: Alprostadil and Phentolamine.
Physical stimulation will help, but is not required to achieve an erection. The resulting erection should last through the entirety of sex, but less than an hour.
Who is it for?
Gel therapy may be an effective choice for patients averse to penile injection therapy as well as those who are unable or unwilling to take oral medications.
Effectiveness
Although not as effective as the injection therapy form of these same ingredients, Intraurethral Gel tends to be a stronger therapy than oral medications.
According to one study conducted over a 6-month period, 37 patients unsatisfied with other treatments opted to proceed with intraurethral gel therapy as their main treatment modality for the management of their ED. Patients responded favorably on their SHIM Score (+9.51 SHIM Score), and all positively responded regarding the medication’s success. 1
Do not exceed the prescribed dose of medication. Do not use more than once in a 24-hour period unless otherwise directed by your physician. Overuse may cause a prolonged erection known as priapism.
Do not use intraurethral gel for sexual intercourse with a woman who is pregnant or may become pregnant unless using a condom barrier to prevent exposure to the medication.
Always store your intraurethral gel in the refrigerator. Do not use medication after it has expired.
Rigidity Scale
Use this tool to rate your erection. For intercourse, the goal range is 7-9 with 6 being firm enough for penetration. For penile rehab, the goal range is 2-9.
Log Your Progress
Use the chart below to record your progress. This chart comes in handy when discussing your treatment success with your provider or with a menMD Personal Health Assistant.
Learn more or download the Injection Therapy Guide, which includes these tools, in the resource center.
Ready to get started?
First you’ll need a prescription.
I have an Rx
If you already have a prescription, login or sign up to get started.
Other treatment options and devices for erectile dysfunction.
Tadalafil
Tadalafil is a common first line ED medication that should be taken 1 hour prior to sex & effective for up to 36 hours.
Comes in 5, 10, & 20 mg tablets and 5 or 20mg lozenges, prescription required.
Bimix
Injection therapy, the most effective treatment for ED, is injected into the shaft of the penis 5-15 minutes prior to intercourse.
2 drug mixture available in 4 formulations, prescription required.
Trimix
Injection therapy, the most effective treatment for ED, is injected into the shaft of the penis 5-15 minutes prior to intercourse.
3 drug mixture available in 11 formulations, prescription required.
Vacuum Erection Devices
The VED is a plastic tube that fits over the penis and is pressed against the base of the penis and pubis. It uses suction to pull blood into the penis to create an erection.
Access Your menMD Account
Manage appointments, prescriptions, and health support in one secure place.
Trustindex verifies that the original source of the review is Google.
Tonya is extremely easy to work with and makes ordering from MenMD a breeze.
Posted on
Tameka Polite
08/08/2025
Trustindex verifies that the original source of the review is Google.
Karen Bono has been such a great help with the clinic that I manage. She is always quick to reply and she always returns my calls. Very professional
Posted on
Joseph Carlton
07/08/2025
Trustindex verifies that the original source of the review is Google.
Great to work with! Super fast and awesome communication!
Posted on
Healthy Solutions
06/08/2025
Trustindex verifies that the original source of the review is Google.
Karen Bono provided me with an absolute amazing experience -5 stars all the way. She reached out and checked in my account while she was away. she really did go above and beyond and still does! I give Karen 10 stars!
Posted on
Christine Ruggiero
05/08/2025
Trustindex verifies that the original source of the review is Google.
I have had a great experience with Shane for the past 3 years. He is incredibly attentive and provides fast responses to any questions I may have. He has been especially helpful when it comes to clarifying pricing details and dosing instruction recommendations. I truly appreciate how thorough and patient Shane has been in addressing my concerns and making the whole process seamless. Highly recommend!
Posted on
Lillian Munguia
01/08/2025
Trustindex verifies that the original source of the review is Google.
Tonya has been fantastic. She goes above and beyond to help get things done. She is the reason I’m a loyal customer at MenMD.
Posted on
Jacqueline Wallace
31/07/2025
Trustindex verifies that the original source of the review is Google.
I’ve had an excellent experience working with menMD, and I want to give a special shout-out to Tonya Schorn, my Account Manager. Tonya has been incredibly responsive, knowledgeable, and genuinely committed to helping whenever an issue arises. She always goes the extra mile to make things right, even when challenges are outside of her control. It’s rare to find support staff who are this dedicated and consistently kind. Thank you, Tonya, for your outstanding service—your hard work does not go unnoticed!
Posted on
Rachel Matson
30/07/2025
Trustindex verifies that the original source of the review is Google.
Tonya Schorn is my account manager. She is very helpful, knowledgeable and resourceful. I am pleased with my continuous service that is provided.
Posted on
Janita Ward
30/07/2025
Trustindex verifies that the original source of the review is Google.
I've had great experiences working with MenMD. In particular, Tonya! She's always prompt, responsive, and incredibly helpful when assisting with prescriptions. I truly appreciate her professionalism and positive attitude. Highly recommend!
Posted on
Karri Wasney
30/07/2025
Trustindex verifies that the original source of the review is Google.
We have been working with Tonya Schorn at MenMD for a few years now! She has been the best rep we have worked with to date. She is very responsive. Like instant response! Which in a clinic is very important as patients need their questions answered promptly. She has helped us navigate ordering, tracking, replacing meds etc very efficiently. She has worked with us diligently to give us fair pricing. Honestly if MenMD could make ALL the meds, we would never look at any other pharmacies ever again for sourcing. I highly recommend Tonya Schorn from MenMD to work with!!!!