Tadalafil

PDE5 Inhibitor

At a Glance

  • Same active ingredient found in Cialis®
  • Take orally, 30 to 60 minutes prior to intercourse
  • Effective for up to 36 hours
  • Available in 5mg and 20mg tablets or lozenges, prescription required
  • Approved to be taken once daily for enlarged prostate (BPH)

The Details

PDE5 (phosphodiesterase type-5) inhibitors like tadalafil work by preventing the body from breaking down the chemicals needed for achieving an erection. This class of oral medications are the American Urologic Association’s recommended first-line treatment for ED.

Tadalafil should be taken up to 36 hours prior to sexual activity and requires sexual stimulation to achieve an erection.

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How it Works

Tadalafil prevents the body from breaking down the chemicals needed to get and maintain an erection. These chemicals are then able to help dilate the corpora cavernosa of the penis, facilitating blood flow which allows for an erection with stimulation.

Tadalafil stays in your system longer than sildenafil, which can provide you with more flexibility in the timing of intercourse.

Who’s it For?

Tadalafil is recommended for men who suffer from erectile dysfunction. Tadalafil may also be prescribed for men who have just had a radical prostatectomy for prostate cancer to help in the recovery process.

Tadalafil can be taken on an as-needed basis or daily. The daily dose is 5mg. Daily tadalafil has been shown to not only improve your erections but can also improve your urinary flow.

DO NOT take tadalafil or other PDE5 inhibitors if you take nitrate medications for cardiac conditions. Talk with your physician before taking tadalafil or other PDE5 inhibitors if you take alpha-blocker medications for high blood pressure or if you have any of the following conditions:

  • Low blood pressure
  • Uncontrolled hypertension
  • Cardiac failure
  • Angina

Effectiveness

Tadalafil is an effective treatment for ED. 15 trials that assessed the use of tadalafil in men with various comorbidities were conducted to determine the mean per-patient percentage of successful intercourse attempts. Based on data collected, tadalafil was reported as having a success rate of 69% (range, 50%–85%) versus 33% for placebo (range, 23%–52%).1

Tadalafil is less affected by meals then sildenafil and other PDE5 inhibitors.

1. NIH National Library of Medicine, Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction

Off-Label Uses

A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For Tadlafil, there are quite a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.

FDA Approved Use

Tadalafil is often recommended as a first-line treatment for men suffering from erectile dysfunction.

BPH

Tadalafil for BPH works by affecting the muscles in the bladder and prostate helping increase urine flow and improve prostate function. Tadalafil has been shown to have positive outcomes for those suffering from issues stemming from BPH.

Climax Control

Tadalafil is recommended for some men who suffer from climax control and some studies have found that PDE5 inhibitors have been effective in helping delay orgasm.1

1. NIH National Library of Medicine, Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis

Prostate Cancer

Tadalafil may also be prescribed for men who have just had a radical prostatectomy for prostate cancer which helps in the recovery process.

Medical Chart

Tadalafil Side Effects

  • Facial flushing
  • Nasal congestion
  • Blurred vision
  • Headaches
  • Heartburn

Good to know

Tadalafil stays in your system longer than sildenafil, which can give you more flexibility in the timing of intercourse.

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