Tadalafil
PDE5 Inhibitor
At a Glance
- Same active ingredient found in Cialis®
- Take orally, 30 to 60 minutes prior to intercourse
- Effective for up to 36 hours
- Available in 5mg and 20mg tablets or lozenges, prescription required
- Approved to be taken once daily for enlarged prostate (BPH)
The Details
PDE5 (phosphodiesterase type-5) inhibitors like tadalafil work by preventing the body from breaking down the chemicals needed for achieving an erection. This class of oral medications are the American Urologic Association’s recommended first-line treatment for ED.
Tadalafil should be taken up to 36 hours prior to sexual activity and requires sexual stimulation to achieve an erection.
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How it Works
Tadalafil prevents the body from breaking down the chemicals needed to get and maintain an erection. These chemicals are then able to help dilate the corpora cavernosa of the penis, facilitating blood flow which allows for an erection with stimulation.
Tadalafil stays in your system longer than sildenafil, which can provide you with more flexibility in the timing of intercourse.
Who’s it For?
Tadalafil is recommended for men who suffer from erectile dysfunction. Tadalafil may also be prescribed for men who have just had a radical prostatectomy for prostate cancer to help in the recovery process.
Tadalafil can be taken on an as-needed basis or daily. The daily dose is 5mg. Daily tadalafil has been shown to not only improve your erections but can also improve your urinary flow.
DO NOT take tadalafil or other PDE5 inhibitors if you take nitrate medications for cardiac conditions. Talk with your physician before taking tadalafil or other PDE5 inhibitors if you take alpha-blocker medications for high blood pressure or if you have any of the following conditions:
- Low blood pressure
- Uncontrolled hypertension
- Cardiac failure
- Angina
Effectiveness
Tadalafil is an effective treatment for ED. 15 trials that assessed the use of tadalafil in men with various comorbidities were conducted to determine the mean per-patient percentage of successful intercourse attempts. Based on data collected, tadalafil was reported as having a success rate of 69% (range, 50%–85%) versus 33% for placebo (range, 23%–52%).1
Tadalafil is less affected by meals then sildenafil and other PDE5 inhibitors.
1. NIH National Library of Medicine, Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction
Off-Label Uses
A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For Tadalafil, there are quite a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.
FDA Approved Use
Tadalafil is often recommended as a first-line treatment for men suffering from erectile dysfunction.
BPH
Tadalafil for BPH works by affecting the muscles in the bladder and prostate helping increase urine flow and improve prostate function. Tadalafil has been shown to have positive outcomes for those suffering from issues stemming from BPH.
Climax Control
Tadalafil is recommended for some men who suffer from climax control and some studies have found that PDE5 inhibitors have been effective in helping delay orgasm.1
1. NIH National Library of Medicine, Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis
Prostate Cancer
Tadalafil may also be prescribed for men who have just had a radical prostatectomy for prostate cancer which helps in the recovery process.
Tadalafil Side Effects
- Facial flushing
- Nasal congestion
- Blurred vision
- Headaches
- Heartburn
Good to know
Tadalafil stays in your system longer than sildenafil, which can give you more flexibility in the timing of intercourse.
Level Up Your Knowledge
Helpful Articles
How An Enlarged Prostate Affects Your Sexual Health
In this article, Dr. Barbalat discusses the importance of treating the bothersome urinary symptoms of BPH and the longterm complications they can cause, while keeping the patient’s sexual function and goals in mind.
Can A Healthy Lifestyle Improve Your ED?
In this article Dr. Loh-Doyle explains how four key lifestyle changes can not only improve your erectile function, but will help you maintain your overall good health.
Having trouble urinating? You may have BPH
In this article Dr. Martinez discusses the symptoms of BPH and prostate cancer, and why it's important to see your urologist for diagnosis and treatment.
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Other products and medications used to treat similar conditions to the product above.
Vacuum Erection Devices
The VED is a plastic tube that fits over the penis and is pressed against the base of the penis and pubis. It uses suction to pull blood into the penis to create an erection.
Intraurethral Gel
Intraurethral gels are injected into the urethra with a needleless syringe 5-15 minutes prior to intercourse.
Available in 3 formulations, prescription required.
Bimix
Injection therapy, the most effective treatment for ED, is injected into the shaft of the penis 5-15 minutes prior to intercourse.
2 drug mixture available in 4 formulations, prescription required.
Finasteride
Finasteride is the same active ingredient as Propecia® and Proscar and is used to treat hair loss or BPH in men.
