2-Drug Intracavernosal Injection

At a Glance

  • A mixture of two medications
  • Must be injected 5 to 15 minutes prior to intercourse
  • Available in 4 formulations
  • Effectiveness ranges from 1 to 2 hours
  • Prescription required

The Details

Bimix injections are a combination of two vasodilators, papaverine and phentolamine. Once injected into the cavernosal tissue of the penis, most patients achieve an erection within 5-15 minutes.

Prescription Required
menMD does not compound or dispense prescription products. Prescriptions are filled through our US-licensed pharmacy partners.

Starts at $87.55 per 5mL Vial

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What to know about Bimix

How it Works

Bimix is a combination of two vasodilators, papaverine and phentolamine. These two medications when injected directly into the penis can increase the strength and duration of erections.

Who’s it For?

Bimix is a proven and effective treatment option for men who suffer from erectile dysfunction. Bimix injections may also be prescribed in conjunction with other ED treatments.

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Auto-Injector Demo


Bimix works very similarly to other ICI therapies but for men who experience penile pain from Trimix injections, Bimix is a great alternative. Injections are one of the most effective forms of ED treatment: up to 92% of patients find injection therapy effective. According to a 2017 study, Bimix formulations were found to be 94% effective in men with erectile dysfunction.1

1. NIH National Library of Medicine, An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study

Off-Label Uses

A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For Bimix, there are a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.

FDA Approved Use

Bimix is often recommended for men suffering from more advanced erectile dysfunction or who have other comorbidities impacting their ED.

Prostate Cancer

Bimix may be prescribed for men who have just had a radical prostatectomy for prostate cancer. Injection Therapy is commonly used to aid in the recovery process.

Medical Chart

Bimix Side Effects

  • Slight pain at the injection site
  • Scarring at injection site (if injections aren’t rotated)
  • Priapism (erection lasting more than 4 hours)

Good to Know

Bimix is not typically used more than 3-4 uses during a single week unless directed by your physician.

All vials, whether punctured or sealed, must be refrigerated. Bimix multi-use vials can be used to 28-days after first puncture. Do not freeze.

Ready to Get Results?

Use these tools to rate and track your progress.

Rigidity Scale
Use this tool to rate your erection. The goal range is 7-9 with 6 being firm enough for penetration.

Log Your Progress
Use the chart below to record your progress. This chart comes in handy when discussing your treatment success with your provider or with a menMD Personal Health Assistant.

Learn more or download the Injection Therapy Guide, which includes these tools, in the resource center.


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Other treatment options for erectile dysfunction.

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Intraurethral Gel

Intraurethral Gel

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Available in 3 formulations, prescription required.