1-Drug Intracavernosal Injection

At a Glance

  • A multi-dose vial of a single ingredient
  • Injection should be done 5 to 15 minutes prior to intercourse
  • Consists of one medication used for injection therapy
  • Requires prescription

The Details

PGE-1 (Alprostadil) injection therapy is a vasodilator that, once injected into the penis, helps increase bloodflow and achieve an erection 5 to 15 minutes before intercourse.

Prescription Required
menMD does not compound or dispense prescription products. Prescriptions are filled through our US-licensed pharmacy partners.

Starts at $97.85 per 5mL Vial

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What to know about PGE-1

How it Works

PGE-1, also referred to as Alprostadil, injection therapy consists of injecting a vasodilator medication directly into the shaft of the penis with a very fine needle. In the case of PGE-1, this injection is usually one of three medications, alprostadil being the most common to inject on its own.

Who’s it For?

PGE-1 injections are best for cases where the oral medications cause intolerable side effects, or if oral medications do not work.

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PGE-1 is one of the three drugs often used for Injection Therapy. Injections are one of the most effective forms of ED treatment: up to 92% of patients find it effective. According to most studies, Prostaglandin E1 (PGE-1) has been found to have an effectiveness rate of approximately 91%.1

1. NIH National Library of Medicine, [Prostaglandin E1 in the diagnosis and therapy of erectile disorders]

Off-Label Uses

A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For PGE-1, there are a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.

FDA Approved Use

PGE-1 is often recommended for men suffering from more advanced erectile dysfunction or who have other comorbidities impacting their ED.

Prostate Cancer

PGE-1 may be prescribed for men who have just had a radical prostatectomy for prostate cancer. Injection Therapy is commonly used to aid in the recovery process.

Medical Chart

PGE-1 Side Effects

  • Scarring at injection site (if injections aren’t rotated)
  • Slight pain at the injection site
  • Priapism (Erection lasting more than 4 hours)
  • Aching sensation in penis

Good to Know

Use of PGE-1 should not exceed 3-4 uses within a single week and no more than once in a 24 hour period unless directed to do so by your physician.

Punctured or sealed vials must be refrigerated. Trimix multi-use vials are safe to use up to 28-days after first puncture. Do not freeze.

Ready to Get Results?

Use these tools to rate and track your progress.

Rigidity Scale
Use this tool to rate your erection. The goal range is 7-9 with 6 being firm enough for penetration.

Log Your Progress
Use the chart below to record your progress. This chart comes in handy when discussing your treatment success with your provider or with a menMD Personal Health Assistant.

Learn more or download the Injection Therapy Guide, which includes these tools, in the resource center.

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Intraurethral Gel

Intraurethral Gel

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Vacuum Erection Devices

Vacuum Erection Devices

The VED is a plastic tube that fits over the penis and is pressed against the base of the penis and pubis. It uses suction to pull blood into the penis to create an erection.