Selective Estrogen Receptor Modulator

At a Glance

  • Oral medication that is taken daily
  • Off-label alternative treatment to standard TRT treatments that helps preserve fertility while increasing testosterone in younger men (<40)
  • More convenient treatment option than gels or injections
  • Can take between 14-30 days to see results
  • Available in 25mg capsules

The Details

Enclomiphene is a Selective Estrogen Receptor Modulator (SERM) used as Testosterone Replacement Therapy for men with secondary Hypogonadism looking to boost their testosterone while reducing the potential effects on their fertility. Enclomiphene is very similar to Clomiphene but it is a stronger antagonist of the Estrogen receptor than Clomiphene.

Prescription Required
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Starting at $2.73 per 25mg capsule

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What to know about Enclomiphene

How it Works

Unlike other Testosterone treatments which increase the amount of testosterone in the body, SERMs like Enclomiphene work instead by reducing reactivity to estrogen in the bloodstream which in turn causes testosterone production to increase and testosterone levels to rise.

Enclomiphene is a stronger antagonist of the Estrogen receptor than Clomiphene and this higher affinity for the Estrogen receptor makes it more specific for the receptor, which decreases estrogen-related side effects.

Who’s it For?

Men of childbearing age with Low-T may choose to use Enclomiphene to avoid the negative effects on fertility, sperm production and testicular size while increasing their testosterone levels.


In multiple studies, Enclomiphene has been found to be effective in raising testosterone levels without damaging male fertility.1, 2. Some studies show a 2x increase in endogenous Testosterone production.

  1. NIH National Library of Medicine, Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men
  2. NIH National LIbrary of Medicine, Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
Medical Chart

Enclomiphene Side Effects

  • Nausea (15%)
  • Flushing (feelings of warmth)
  • Headaches
  • Bloating and Weight gain

Good to Know

Enclomiphene therapy is not recommended for men with primary hypogonadism, or men who have high levels of circulating gonadotropins (Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH)) with concurrent low testosterone. Enclomiphene monotherapy is also not recommended to be the primary choice of treatment for low testosterone for men that do not require to preserve fertility, as testosterone injections are the most reliable way to alleviate symptomatic low T.

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Don’t forget to check these out

Other treatment options for testosterone replacement.



A rapid dissolve tablet, placed between the cheek and gum or on the tongue, taken daily to help boost testosterone levels. Prescription required.

Testosterone Cypionate Injections

Testosterone Cypionate Injections

Testosterone Cypionate injections are a safe, effective way to treat hypogonadism or low-T.

Testosterone Pellets

Testosterone Pellets

Testosterone Pellets are placed under the skin under a local anesthetic and release testosterone consistently into the bloodstream over 4-6 months.

Testosterone Topical Gel

Testosterone Topical Gel

Testosterone topical gels are a simple way to replace testosterone daily without using needles or undergoing an in-office procedure.