4-Drug Intracavernosal Injection
At a Glance
- A mixture of four medications
- Inject into shaft of penis 5 to 15 minutes prior to intercourse
- Effective for 1 to 2 hours
- Prescription required
Quadmix is a 4-drug erectile dysfunction medication injected into the cavernosal tissue of the penis with a very fine needle before intercourse. The medication works by relaxing the corporal smooth musculature and/or building the adrenergic tone of the corporal smooth muscle. This allows for Increased blood flow to the penis to achieve and maintain an erection strong enough for sexual intercourse.
Quadmix should be injected 5-15 minutes prior to sexual activity.
menMD does not compound or dispense prescription products. Prescriptions are filled though our US licensed pharmacy partners.
Starts at $105 per vial
What to know about Quadmix
How it Works
Quadmix is injected into the cavernosal tissue of the penis with a very fine needle just before intercourse. The medication works by relaxing the corporal smooth musculature and/or building the adrenergic tone of the corporal smooth muscle.
This allows for Increased blood flow to the penis to achieve and maintain an erection strong enough for the entirety of sexual intercourse.
Who’s it For?
Quadmix injections are recommended for men who suffer from erectile dysfunction who have not had success using PGE-1, Bimix, or Trimix. The four drugs in this mixture work synergistically together to produce a stronger result than Trimix. Quadmix may also be used in conjunction with other Erectile Dysfunction therapy modalities such as PDE5-inhibitors.
DO NOT inject Quadmix more than once in a 24-hour period unless instructed to do so by your Physician. Patients must be cautioned to call their physician if an erection persists for 4 hours or longer.
Injections are one of the most effective forms of ED treatment: up to 92% of patients find it effective. In a study conducted by the British Medical Journal, 88% of patients who failed to respond to PDE5-Inhibitors (Viagra, Cialis, Levitra) were successful with injection therapy. Additionally 48% of men who failed to respond to PDE5-inhibitors responded when used in conjunction with injection therapy.
According to a Continuing Medical Education (CME) Article, of the men who stop using injection therapy, 82% of them would still recommend it to a friend.
A common practice, off-label prescribing is when a doctor prescribes a drug for a different condition or at a different dosage than the FDA has approved. For Quadmix, there are a few conditions prescribed off-label. Always consult your physician before beginning a new treatment or modifying your existing treatment.
FDA Approved Use
Quadmix is often recommended for men suffering from more advanced erectile dysfunction or who have other comorbidities impacting their ED.
Quadmix may be prescribed for men who have just had a radical prostatectomy for prostate cancer. Injection Therapy is commonly used to aid in the recovery process.
Quadmix Side Effects
- Priapism (erection lasting more than 4 hours)
- Aching sensation in penis
- Scarring at injection site (if injections aren’t rotated)
Good to Know
Do not exceed the maximum prescribed dose without consulting your urologist. Do not inject more than once in a 24-hour period unless otherwise directed by your physician. Most doctors recommend no more than 3-4 times weekly to minimize scar tissue formation.
All vials, whether punctured or sealed, must be refrigerated. Quadmix multi-use vials are safe to use up to 28-days after the first puncture. Do not freeze.
Level Up Your Knowledge
Essential Medication Travel Checklist: How to Pack and Prepare for Your Journey
In this article, we offer a comprehensive checklist to facilitate seamless packing and readiness for your travels, promoting worry-free exploration. A primary step is to organize prescriptions, meticulously noting medications, dosages, and frequencies.
Can A Healthy Lifestyle Improve Your ED?
In this article Dr. Loh-Doyle explains how four key lifestyle changes can not only improve your erectile function, but will help you maintain your overall good health.
Multi-dose Vials and the 28-day Sterility Rule
In this article Patrick Carpenter, Pharmacist discusses safety guidelines for the use of injectable medicines in multi-dose vials.
For instructions and how-to’s, visit our resource center.
Ready to Get Results?
Use these tools to rate and track your progress.
Use this tool to rate your erection. The goal range is 7-9 with 6 being firm enough for penetration.
Log Your Progress
Use the chart below to record your progress. This chart comes in handy when discussing your treatment success with your provider or with a menMD Personal Health Assistant.
Learn more or download the Injection Therapy Guide, which includes these tools, in the resource center.
Ready to get started?
First you’ll need a prescription.
Don’t forget to check these out
Other treatment options for erectile dysfunction.
Vacuum Erection Devices
The VED is a plastic tube that fits over the penis and is pressed against the base of the penis and pubis. It uses suction to pull blood into the penis to create an erection.
Injection therapy, the most effective treatment for ED, is injected into the shaft of the penis 5-15 minutes prior to intercourse.
3 drug mixture available in 11 formulations, prescription required.
Intraurethral gels are injected into the urethra with a needleless syringe 5-15 minutes prior to intercourse.
Available in 3 formulations, prescription required.