Surgery & Peyronie's Disease (PD) | menMD

Treatment Options


Peyronie's Disease Treatment Options

Surgical Treatments for Peyronie's Disease

Surgery is typically considered a second line treatment for Peyronie’s. Surgical procedures have proven to be effective at partial resolution of penile curvature. Surgeries should only be performed in men who with stable disease, meaning no change in curvature and no penile pain for a minimum of 6 months. Oral, topical, injection, and traction therapy treatments may be prescribed by your physician to help stabilize the scarring process prior to a surgical procedure for the treatment of PD.

There are two primary surgeries performed for PD: penile plication surgery and incision/excision and grafting.

Penile Plication

During penile plication the surgeon will remove or alter the tissue on the side of the penis opposite the plaque to counter the disease’s bending effect. Side effects of plication include visible sutures, temporary post surgical pain and bruising, and reduced penile size.

Incision / Excision and Grafting

Incision / excision and grafting involves cutting the scar tissue and placing a graft over the newly created space. Side effects of incision / excision and grafting can lead to erectile dysfunction or changes in penile sensation. Although the penile length usually does not change by much with either surgery, the overall volume of the penis is reduced, which often gives patients the perception of length loss. There is limited long-term data available on surgery, with some showing that penile curvature returns in a percentage of men.


For men with both Peyronie’s Disease and erectile dysfunction who don’t respond to PDE5i oral medications the physician may recommend a penile implant.

Helpful Articles

Available Options

Pentoxifylline Tablets


Available in 400mg tablets

May prevent continued scaring, improve erection quality through improved blood circulation, and help reduce the calcification of penile plaque.

Verpamil Cream

Verapamil HCL Topical Cream

Verapamil 12% available in 30mL pump dispenser

May be prescribed in combination with Verapamil penile injections as directed by the physician.

Verpamil Injection

Verapamil HCL Intralesional Injection

Available in 2.5mg/mL and 4mL vials

May help stabilize penile scarring, increase blood flow, and reduce deformation. Verapamil injection medication is shipped directly to the physician’s office for administration by a trained healthcare provider.

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