Treatment Options


Treatment Options

Medications for Peyronie's Disease

Oral Medications

Oral medications such as generic Pentoxifylline tablets may help stabilize the penile scarring process. Well-known brand names for Pentoxifylline are Trental™, Pentox™, Pentoxil™ and Flexital™.

When taken over a period of months Pentoxifylline may prevent continued scaring, improve erection quality through improved blood circulation, and help reduce the calcification of the plaque.

Pentoxifylline seems to be generally well tolerated. Most common side effects include nausea, vomiting, diarrhea, headache, dizziness, blurred vision, insomnia and drowsiness. Taking Pentoxifylline with meals may help prevent an upset stomach.

It is not recommended to take Pentoxifylline if the patient had a recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.

Pentoxifylline is not FDA approved for the treatment of Peyronie’s disease.

Penile Injections

Injection therapy may be prescribed to help stabilize the penile scarring process. The prescribed injection medicine used is patient specific. A physician may prescribe a series of Verapamil, Interferon, or Xiaflex® intralesional penile injections over a period of several months which may stabilize the scarring, increase blood flow, and reduce the deformation. The injections are done at a medical facility and administered by a trained healthcare provider.

Verapamil is not recommended for patients with severe heart abnormalities, low blood pressure, poor heart function, certain heart rhythm problems, certain types of blockages in the heart called second or third degree atrioventricular (AV) block, rapid heart rate or any allergic reaction to Verapamil. Avoid grapefruit and grapefruit juice when taking Verapamil.

Verapamil and Interferon are not FDA approved for the treatment of Peyronie’s, but have been used historically to treat this disease. Xiaflex® is FDA approved for the treatment of Peyronie’s.

Injections + Topical Cream

Verapamil injections may be prescribed in combination with Verapamil topical cream. The topical creams may be prescribed for daily use between injection therapy sessions.

Injections + Oral Medications

Pentoxifylline may be prescribed in combination with injection therapy to stabilize the penile scarring process. In one study using three control groups. The first group used Pentoxifylline, the second group Verapamil, and the third group used a combination therapy of both medications. No significant difference was seen between the two groups using verapamil or Pentoxifylline, but there was a significant improvement in combination therapy group. Due to their results they proposed that combination therapy can improve results and should be considered as a choice in treatment of penile scarring and the resulting curvature.1 Source

Helpful Articles

Available Options

  • Pentoxifylline

    400mg Tablets

  • Verapamil HCL Topical Cream

    12% Topical Cream

  • Verapamil HCL Intralesional Injection

    2.5mg/mL Intralesional Injection

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